Preliminary study of metabonomcs on aqueous extract of Evodia rutaecarpa in sprague-dawley rats.

Author: Qiyun ZHANG ¹ ; Guoliang XU ; Licun WU ; Xiaoxue MA ; Zhijun ZENG ; Liping HUANG ; Riyue YU ; Hongning LIU
Author Information

1. Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Publication Type:Journal Article
MeSH: Animals; Evodia; chemistry; Female; Gene Expression; drug effects; Male; Metabolomics; methods; Plant Extracts; pharmacology; Principal Component Analysis; Rats; Rats, Sprague-Dawley
From: China Journal of Chinese Materia Medica 2010;35(1):99-102
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the change of endogenous metabolites of SD rats administrated of aqueous extract of Evodiae rutaecarpa.
METHODSix SD rats had been successively administrated aqueous extract of E. rutaecarpa (0.3857 g x kg(-1)) for 33 days. An agilent 1200 6410 triplequadrupole mass spectrometer was used for the analysis of endogenous metabolites in rat urine samples. These data was analyzed by the principal component analysis (PCA) and PLS-DA using the SIMCA-P 10.0 software.
RESULTThe significant difference in metabolic profiles between the control group and the dosed group was well observed by PCA of the MS data.
CONCLUSIONThe E. rulaecarpa has changed the endogenous metabolites of SD rats. This work can provide the base for the further research on the interpretation of drug property of E. rulaecarpa.