Preparation of submicron emulsion of fresh Zhongjiefeng volatile oil.
- Author:
Suxiang WU
1
;
Guiyuan LV
;
Suhong CHEN
;
Shengna ZHANG
;
Lishan ZHAO
;
Rihe ZHOU
;
Huakang ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Drug Stability; Drugs, Chinese Herbal; chemistry; Emulsions; chemistry; Oils, Volatile; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(24):3199-3202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare the submicron emulsion of fresh Zhongjiefeng volatile oil.
METHODThe Zhongjiefeng volatile oil submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer. The physical and chemical stability of the emulsion was evaluated with the stability parameter of centrifugation, appearance of emulsion and the pH. The formulation and processing factors were optimized by single factor reviewing and orthogonal experimental design.
RESULTBy controlling various processing factors and optimizing formulation, the stable submicron emulsion of Zhongjiefeng volatile oil was prepared. Its mean particle diameter was 164-169 nm with PDI 0.084-0.107 and Zeta electric potential was -40 mV.
CONCLUSIONThe formulation and preparation technique of the emulsion is reasonable.
