Study on in vitro mucosal permeation properties and factors affecting mucosal permeability of paeonol.
- Author:
Xiaolan CHEN
1
;
Shouying DU
;
Yang LU
;
Zongling YAO
Author Information
- Publication Type:Journal Article
- MeSH: Acetophenones; metabolism; Animals; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; In Vitro Techniques; Mucous Membrane; metabolism; Osmotic Pressure; Permeability; Rana catesbeiana; metabolism; Skin; metabolism
- From: China Journal of Chinese Materia Medica 2009;34(24):3207-3210
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the in vitro mucosal permeation properties of paeonol and the factors that affect such permeability.
METHODBullfrog skin was selected as the permeation model, and the modified Franz diffusion cell was adopted to investigate the percutaneous adsorption in vitro. Content of paeonol was quantified by HPLC. Kinds of receiving solution, parts of bullfrog skin and impacts of drug concentration on percutaneous adsorption in vitro were systematically studied.
RESULTPercutaneous permeation of paeonol was to some extent affected by osmotic pressure and pH value of the receiving solution. Abdominal skin, lateral abdominal skin and dorsal skin, with the permeability coefficient form high to low, had great influence on the permeation of paeonol. There existed a good percutaneous permeation of paeonol. And the relationship between the cumulative permeability rate and time was coincided with the first order kenetical process.
CONCLUSIONTake the in vitro abdominal skin of bullfrog as the permeation model, some similarities are revealed between in vitro percutaneous permeation of paeonol and mucosal adsorption.
