Optimization of cataplasm matrix with face-centered design-response surface method.
- Author:
Shuzhi LIU
1
;
Junhong LI
;
Rixian JIN
;
Maobo DU
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; methods; Drugs, Chinese Herbal; chemistry; Models, Theoretical
- From: China Journal of Chinese Materia Medica 2009;34(24):3211-3213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the matrix formulation of cataplasm.
METHODFace-centered design was used in the experimental design, and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate, Carbomer and the cross-linking agent on stickiness of cataplasm, optimize the prescription of the cataplasm matrix and perform the evaluation analysis.
RESULTThe multiple correlation coefficient (R2) and adjusted R2 in the fitting method using quadratic polynomial were 0.970 and 0. 952 (F = 53.953, P = 0.0001), respectively, and the model was significant different. The ratio of optimum proportion of Sodium Polyacrylate, Carbomer and the cross-linking agent in the matrix of cataplasm was determined, which was proved efficaciously.
CONCLUSIONFace-centered design-response surface method is a simple method with good prediction result for the optimization of cataplasm matrix.
