Chemical constituents of Periploca forrestii and their cytotoxicity activity.
- Author:
Jin WANG
1
;
Cuifang WANG
;
Jinxiong CHEN
;
Jiang DU
;
Dewen QIU
;
Minghua QIU
Author Information
- Publication Type:Journal Article
- MeSH: Cell Line, Tumor; Cell Survival; drug effects; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Periploca; chemistry; Plant Roots; chemistry; Triterpenes; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2009;34(24):3214-3216
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities.
METHODSilica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62).
RESULTFour compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin (4).
CONCLUSIONCompound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.
