Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS.
- Author:
Ai-Hua ZUO
1
;
Meng-Chun CHENG
;
Li WANG
;
Hong-Bin XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; drug effects; metabolism; Chromatography, High Pressure Liquid; methods; Drugs, Chinese Herbal; administration & dosage; analysis; pharmacokinetics; Female; Humans; Ligusticum; chemistry; Mass Spectrometry; methods; Rats; Rats, Sprague-Dawley; Rhizome; chemistry
- From: China Journal of Chinese Materia Medica 2012;37(23):3647-3650
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts.
METHODThe dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data.
RESULTAfter oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide.
CONCLUSIONThe study is helpful for interpreting effective substance of Ligusticum chuanxiong.
