Studies on metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria.
- Author:
Shuang LI
1
;
Cheng-Wang TIAN
;
Shuai WU
;
Xiu-Wei YANG
;
Li-Li WANG
;
Tie-Jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; metabolism; Anaerobiosis; Bacteria; metabolism; Chromatography, High Pressure Liquid; Humans; Intestines; metabolism; microbiology; Ketones; metabolism; Mass Spectrometry; Swertia; metabolism; Terpenes; metabolism; Xanthones; metabolism
- From: China Journal of Chinese Materia Medica 2012;37(24):3743-3747
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria.
METHODTotal terpene ketones were incubated with human intestinal bacteria under an anaerobic environment and at 37 degrees C. The metabolites were extracted by ethyl acetate processing, detected by HPLC-DAD method. A qualitative analysis was made for its metabolites by HPLC-MS.
RESULTEight metabolites were detected from total terpene ketones from S. mussotii with human intestinal bacteria, and two of them were preliminarily identified as gentianine and mangiferin aglycon.
CONCLUSIONTotal terpene ketones can be metabolized with human intestinal bacteria, which provides basis for experiments on the metabolism process total terpene ketones from S. mussotii with human intestinal bacteria.
