Advance in studies on effect of paeoniflorin on nervous system.
- Author:
Zeng-Yao HU
1
;
Lan XU
;
Rong YAN
;
Yan HUANG
;
Gang LIU
;
Wen-Xia ZHOU
;
Yong-Xiang ZHANG
Author Information
1. Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Benzoates;
pharmacology;
Bridged-Ring Compounds;
pharmacology;
Calcium Channels;
metabolism;
Glucosides;
pharmacology;
Learning;
drug effects;
Memory;
drug effects;
Monoterpenes;
NF-kappa B;
metabolism;
Nervous System;
drug effects;
metabolism;
Receptor, Adenosine A1;
metabolism
- From:
China Journal of Chinese Materia Medica
2013;38(3):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Paeoniflorin (PF) is the chief active component of paeonia, with diverse pharmacological actions and wide application. Recently, the effect of PF on nervous system has attracted increasingly more attention. According to current study findings, PF can ameliorate the decline of memory and learning capacities in many dementia model animals, and have effect in protecting the cerebral ischemia injury, treating Parkinson's disease, reliving pain and improving neural synapse plasticity. Thought its mechanism has not been clarified, current findings show that adenosine A1 receptor plays an important role, while M cholinergic receptor, opiate receptor, calcium ion channel and NF-KB may also play a part in paeoniflorin's effect on nervous system.
