A pilot study on hypoxia of squamous cell carcinoma in oral cavity

VernacularTitle:口腔鳞状细胞癌组织乏氧状况的初步研究
Author: Wen-Shu LIU ¹ ; Jian-Wei SHANG ; Yan GAO ; Chuan-Bin GUO
Author Information

1. 北京大学口腔医学院(口腔医院)
Keywords: Carcinoma,squamous cell; Tomography,emission-computed,single-photon; Antineoplastic protocols
From: Chinese Journal of Stomatology 2009;44(5):282-285
CountryChina
Language:Chinese
Abstract: Objective To examine the extent of hypoxia in oral squamous cell carcinoma and investigate the factors related to the hypoxia.Methods An animal model of oral squamous cell carcinoma was established and single photon emission computed tomography(SPECT)with 99m Tc-H191 used to detect tlle hypoxia extent of the oral squamous cell carcinoma.The expression of hypoxia inducible factor 1 alpha (HIF-1α)was examined by immunohistochemical staining in 42 cases of formalin-fixed paraffin-embed squamous cell carcinoma.Results The uptake of 99m Tc-HL91 in the tumor tissue was higher than that in normal tissue and had linear relation with the tumor size(P＜0.05).There was no HIF-1α expression in the normal oral mucosm The expression of HIF-1α was high in oral mucosa carcinoma and closely related to the differentiation degree of tumor and metastasis of lymph node(P＜0.05).Conclusions Tumor tissue had broad hypoxic region.HIF-1α highly expressed in oral squamous cell carcinoma and may play an important role in carcinogenesis and aggression.