Correlation between the expression of cytokeratin-18-mRNA and invasion and metastasis of oral squamous cell carcinoma

VernacularTitle:细胞角蛋白18-mRNA的表达与口腔鳞状细胞癌侵袭转移的关系
Author: Ping SHU ¹ ; De-An ZHAO ; Da-Peng LU
Author Information

1. 首都医科大学口腔医学院
Keywords: Carcinoma,squamous cell; Cytokeratin 18; Neoplasm metastasis
From: Chinese Journal of Stomatology 2009;44(5):286-288
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the expression of eytokeratin(CK)-18 and biological behavior of oral squamous cell carcinoma(OSCC).Methods Twenty-three patients with OSCC were investigated for the expression of CK-18-mRNA by semi-quantitative reverse transcriptasepolymerase chain reaction(RT-PCR).Correlations between clinical stages,pathological differentiation,lymphatic metastasis and the expression of CK-18-mRNA were evaluated.CK-18-mRNA expression of peripheral blood from the 23 patients and 23 healthy people were also examined.During follow-up after operation,the peripheral blood wag collected again for the expression of CK-19-mRNA.Results Expression of CK-18-mRNA was found in 16 patients.The expression of CK-18-mRNA was significandy associated with clinical stages.tumor differentiation and lymphatic metastasis.CK-18-mRNA Was positive in 4 of 23 blood specimens before operation,but during follow-up only 1 of 23 patients was still positive in peripheral blood.Conclusions CK-18 may provide additional information in forecasting the metastasis of OSCC and serve as a reference in monitoring recurrence.