Effects of simvastatin on the immune-related genes of mouse osteoblasts.

Author: Fei HU ¹ ; Xue-yang ZHANG ; Lei ZHOU
Author Information

1. Department of Orthodontics, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.
Publication Type:Journal Article
MeSH: Animals; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation; Mice; Osteoblasts; drug effects; immunology; Osteogenesis; drug effects; Simvastatin; pharmacology
From: Chinese Journal of Stomatology 2009;44(4):222-226
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the expression of immune-related genes during osteogenesis stimulated by simvastatin.
METHODSAfter treated with simvastatin, the expression of immune-related genes of mouse osteoblast was examined with gene chip (BiostarM-140s).
RESULTSThere were 16 differently expressed genes related to immune function, with nine down-regulated genes and seven up-regulated genes.
CONCLUSIONSAfter treated with simvastatin, expression of inflammation related genes is down-regulated and inflammation inhibitor genes is up-regulated in mouse osteoblasts.