Effects of simvastatin on the immaune-related genes of mouse osteoblasts

VernacularTitle:辛伐他汀对小鼠成骨细胞免疫相关基因表达的研究
Author: Fei HU ¹ ; Xue-Yang ZHANG ; Lei ZHOU
Author Information

1. 广东省口腔医院
Keywords: Simvastatin; Osteoblasts; Immunity; Cene expression
From: Chinese Journal of Stomatology 2009;44(4):222-226
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of immune-related genes during osteogenesis stimulated by simvastatin. Methods After treated with simvastatin, the expression of immune-related genes of mouse ostenhlast was examined with geue chip (BiostarM-140s). Results There were 16 differendy expressed genes related to immune function, with nine down-regulated genes and seven up-regulated genes.Conclusions After treated with simvastatin, expression of inflammation related genes is down-regulated and inflammation inhibitor genes is up-regulated in mouse osteoblasts.