Serum C-reactive protein levels and lipid profiles concentrations in moderate to severe periodontitis and coronary heart disease: a comparative study
10.3760/cma.j.issn.1002-0098.2009.03.008
- VernacularTitle:中、重度牙周炎与冠心病患者C反应蛋白及血脂水平的比较
- Author:
Juan LIU
1
;
Ya-Fei WU
;
Yi DING
;
Song GE
;
Li RAO
;
Hong TANG
Author Information
1. 四川大学华西口腔医学院
- Keywords:
C-reactive protein;
Periodontitis;
Coronary disease;
Risk factors
- From:
Chinese Journal of Stomatology
2009;44(3):150-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between moderate to severe periodontitis and coronary heart disease (CHD) and to examine the serum C-reactive protein (CRP) levels in subjects with CHD and/or moderate to severe periodontitis.Methods Serum CRP levels, serum lipids [low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), total cholesterol (TC) and triglyceride(TG)] and clinical periodontal parameters [clinical attachment loss (CAL), probing depth (PD), and bleeding on probing (BOP)] were measured and analyzed in coexistant moderate to severe periodontitis and CHD patients (n = 47), CHD patients (n = 28), moderate to severe periodontitis patients (n=40), and healthy subjects (n =40).Results The serum CRP levels in control group, moderate to severe periodontitis patients, CHD patients and patients with both diseases were (1.30±0.15), (2.44±0.18), (5.99±0.82) and (6.88±0.71) mg/L, respectively.The differences among these four groups were significant (P < 0.001).The multivariate logistic regression revealed that moderate to severe periodontitis patients exhibited markedly elevated odds of having CHD (OR = 2.417, 95% CI: 1.126-6.659).The total cholesterol levels were also significantly different among the four groups (P = 0.017).Conclusions The moderate to severe periodontitis was associated with elevated serum CRP levels which may in turn affect the initiation and progression of CHD, and may be a risk factor for CHD.
