Expression of survivin, Bcl-2 and p53 during 4-nitro-quinoline 1-oxide-induced rat tongue carcinogenesis.
- Author:
Yan-Fen ZHENG
1
;
Zuo-Liang CHEN
;
Hong-Bo CHEN
;
Jun CHENG
Author Information
- Publication Type:Journal Article
- MeSH: 4-Nitroquinoline-1-oxide; adverse effects; Animals; Apoptosis; Cell Transformation, Neoplastic; chemically induced; metabolism; pathology; Genes, bcl-2; Male; Microtubule-Associated Proteins; metabolism; Mouth Mucosa; metabolism; pathology; Proto-Oncogene Proteins c-bcl-2; metabolism; Rats; Tongue Neoplasms; chemically induced; metabolism; pathology; Tumor Suppressor Protein p53; metabolism
- From: Chinese Journal of Stomatology 2009;44(3):168-171
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of survivin during oral carcinogenesis and its relationship with the expression of Bcl-2 and p53.
METHODSTwo-step immunohistochemical method was employed to detect the expression of survivin, Bcl-2 and p53 in 60 rat tongue carcinogenesis specimens induced by 4-nitro-quinoline 1-oxide (4NQO).
RESULTSSurvivin was present in 1/36 cases of normal mucosa, 6/11 cases of oral epithelial dysplasia and 10/11 cases of oral carcinoma. There were significant difference in the expression of survivin among normal mucosa, oral epithelial dysplasia and carcinoma (P < 0.001). While in the 17 cases of positive expression of survivin, Bcl-2 was present in 12 cases and p53 was present in 8 cases. The expression of survivin in oral epithelial dysplasia and carcinoma were significantly higher than that in normal oral mucosa (P < 0.01). The expression of survivin was positively correlated to the expression of Bcl-2 and p53 in rat tongue (P < 0.01).
CONCLUSIONSThe expression of survivin may play an important role in oral carcinogenesis. Survivin, Bcl-2 and p53 may be synergetic in the carcinogenesis of oral cancer.
