Therapeutic efficacy of pralidoxime chloride on acute dichlorvos poisoning.
- Author:
Qiu-hong ZHU
1
;
Jin-xiang HUANG
;
Zheng LIN
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Adult; Animals; Antidotes; therapeutic use; Cholinesterases; blood; Dichlorvos; poisoning; Female; Humans; Insecticides; poisoning; Male; Mice; Mice, Inbred Strains; Middle Aged; Poisoning; blood; drug therapy; Pralidoxime Compounds; therapeutic use; Rats; Rats, Sprague-Dawley; Treatment Outcome
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2005;23(2):91-93
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic efficacy and mechanism of oxime drug, pralidoxime chloride (PAM-Cl), on acute dichlorvos (DDV) poisoning.
METHODSThe toxic signs and survival rate were recorded and ChE activity in blood was determined in treatment group with PAM-Cl and non-treatment group after DDV was given to rats and mice by gastrogavage; the therapeutic efficacy and reactivation of DDV-inhibited ChE by PAM-Cl were observed on the patients with acute DDV poisoning.
RESULTS(1) The alleviated and delayed toxic signs as well as higher survival rate were found in PAM-Cl treatment group compared with non-treatment group. (2) After the rats were exposed to DDV, the ChE activities of whole blood in different time within 24 h were statistically significantly higher in PAM-Cl treatment group than in non-treatment group (P < 0.05). (3) After PAM-Cl treatment, muscular fasciculation and other nicotinic signs in poisoned patients were disappeared and the inhibited blood ChE activities were gradually reactivated to normal level.
CONCLUSIONPAM-Cl has therapeutic efficacy against acute toxicity of DDV through its reactivation of inhibited ChE.
