Influence of 1.8 GHz microwave on DNA damage induced by 4 chemical mutagens.
- Author:
Bao-hong WANG
1
;
De-qiang LU
;
Li-fen JIN
;
Wei ZHENG
;
Jian-lin LOU
;
Hong-ping DENG
;
Qing-yu LI
;
Ji-liang HE
Author Information
- Publication Type:Journal Article
- MeSH: 4-Nitroquinoline-1-oxide; toxicity; Adult; Bleomycin; toxicity; Cells, Cultured; Comet Assay; DNA; drug effects; DNA Damage; Humans; Lymphocytes; drug effects; radiation effects; Male; Methyl Methanesulfonate; toxicity; Microwaves; adverse effects; Mitomycin; toxicity; Mutagens; toxicity
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2005;23(3):163-166
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the influence of 1.8 GHz microwave (MW) specific absorption rate (SAR, 3 W/kg) on human lymphocytes DNA damage induced by 4 chemical mutagens [mitomycin C (MMC), bleomycin (BLM), methyl methanesulfonate (MMS), and 4-nitroquinoline 1-oxide (4NQO)].
METHODSComet assay in vitro was used to detect human lymphocyte DNA damage induced by 1.8 GHz MW, 4 chemical mutagens, and MW plus 4 chemicals 0 h and 21 h respectively after exposure. The time exposed to MW or mutagens was 2 h or 3 h respectively. The results were showed by tail length (TL) and tail moment (TM).
RESULTSThe difference of DNA damage between MW group and control group was not statistically significant (P > 0.05). DNA damages in MW plus MMC groups and MW plus 4NQO groups were significantly greater than those in the corresponding concentrations of MMC groups and 4NQO groups (P < 0.01 or P < 0.05). However, MW did not enhance DNA damage induced by MMS and BLM (P > 0.05).
CONCLUSIONExposure to 1.8 GHz (SAR, 3 W/kg) microwave may not induce human lymphocyte DNA damage, but could enhance DNA damage induced by MMC and 4NQO.
