Changes of the expression of beta1-adrenergic receptor and M2-muscarinic acetylcholine receptor in rat hearts after high power microwave radiation.
- Author:
Min-hong PAN
1
;
Rui-yun PENG
;
Ya-bing GAO
;
Shui-ming WANG
;
Jun-jie MA
;
De-wen WANG
;
Wen-hua HU
;
Zhen-tao SU
;
Guo-shan YANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Dose-Response Relationship, Radiation; Heart; radiation effects; Male; Microwaves; adverse effects; Myocytes, Cardiac; metabolism; radiation effects; Rats; Rats, Wistar; Receptor, Muscarinic M2; biosynthesis; Receptors, Adrenergic, beta-1; biosynthesis
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2005;23(3):172-174
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of high power microwave (HPM) radiation on the expression of beta(1)-adrenergic receptor (beta(1)-AR) and M(2)-muscarinic acetylcholine receptor (M(2)-AchR) in cardiomyocytes.
METHODSS-band HPM device of mean power density 2 approximately 90 mW/cm(2) was used to irradiate 150 healthy Wistar male rats. Immunohistochemistry and image analysis were used to study the pathological characteristics of heart tissue and the expression of beta(1)-AR and M(2)-AchR.
RESULTSRadiation of over 10 mW/cm(2) made myocardial fibers disordered in arrangement, degeneration even sarcoplasm condensation, Pace cells necrosis, and Purkinje cells lysis in a dose-dependent manner (r = 0.968, P < 0.05). beta(1)-AR expression in endocardium, membrane and cytoplasm of myocardium of left ventricle was increased on d1 after radiation, peaked on d3 (P < 0.05) and recovered on d14. M(2)-AchR expression was peaked on d1 (P < 0.01) and recovered on d14.
CONCLUSIONCertain degree intensity of HPM radiation may cause heart injury, and increased expressions of beta(1)-AR and M(2)-AchR, which may play an important role in the pathophysiology of heart injury induced by HPM.
