Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix.
- Author:
Rong XING
1
;
Kai ZHOU
;
Jia-Wei SONG
Author Information
1. The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China. xingrong9796@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
administration & dosage;
pharmacokinetics;
Astragalus Plant;
chemistry;
Chromatography, High Pressure Liquid;
Drug Interactions;
Drugs, Chinese Herbal;
administration & dosage;
Female;
Humans;
Male;
Quinazolines;
administration & dosage;
pharmacokinetics;
Rats;
Rats, Sprague-Dawley;
Thiophenes;
administration & dosage;
pharmacokinetics
- From:
China Journal of Chinese Materia Medica
2013;38(11):1823-1826
- CountryChina
- Language:Chinese
-
Abstract:
To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups: RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.
