Preparation and in vitro evaluation of self-assembled beads drug delivery system of berberine hydrochloride.
- Author:
Chuan LIU
1
;
Yani XU
;
Hui OUYANG
;
Tao YI
Author Information
1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
- Publication Type:Journal Article
- MeSH:
Berberine;
administration & dosage;
Drug Delivery Systems;
Particle Size;
Solubility;
Soybean Oil;
administration & dosage;
alpha-Cyclodextrins;
administration & dosage
- From:
China Journal of Chinese Materia Medica
2013;38(12):1924-1928
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of the present work was to investigate the innovative self-assembling system, "beads", prepared by continuously shaking alpha-cyclodextrin and soybean oil without the use of organic solvents and surfactants at room temperature. Berberine hydrochloride previously dissolved in soybean oil was chosen as a model drug to explore the shape, structure, drug loading and in vitro release of beads. The particle size and drug loading of berberine hydrochloride-loaded beads were (2.25 +/- 0.23) mm and (67.02 +/- 0.64) microg x g(-1), respectively. Confocal microscopy showed that the core-shell structure of beads could contain poorly water soluble drugs or lipophilic drugs in the lipid core. The drug release rate and cumulative releases of beads were both higher than those of raw medicine of berberine hydrochloride in simulated intestinal fluid. These results suggested that beads were the novel and potential lipid-based drug delivery system for lipophilic or poorly water soluble traditional Chinese medicine.
