Protective effect of yixinshu capsule on myocardial ischemia reperfusion injury in rats.
- Author:
Jia-Wen LIU
1
;
Xin-Yi LIU
;
Jian-He LI
;
Da-Xiong XIANG
;
Li-Dan YI
;
Xiong-Bin HU
;
Zu-Guang YE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Viscosity; drug effects; Capsules; Drugs, Chinese Herbal; therapeutic use; Lipid Peroxidation; drug effects; Male; Myocardial Infarction; drug therapy; metabolism; pathology; Myocardial Reperfusion Injury; prevention & control; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2013;38(12):2005-2008
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury (MIRI) in SD rats.
METHODSixty healthy SD rats were randomized into six groups: sham group, MIRI model group, Xinsuning capsule group, low, middle or high dose Yixinshu capsule. Acute MIRI rat models were created by reperfusion for 120 min after anterior interventricular branch of the left coronary artery for 30 min. The serum creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and malondialdehyde(MDA), blood viscosity, and infarction area of myocardium were determined.
RESULTYixinshu capsule could reduce serum CK, LDH, AST and LDH activity, improve the blood viscosity, and reduced the myocardial infarct size.
CONCLUSIONYixinshu capsule can protect against MIRI in rats.
