Preparation and in vitro permeation of tetramethylpyrazine hydrochloride transdermal gel.
- Author:
Zhan TANG
1
;
Hong-Yan XU
;
Qiao WANG
Author Information
1. Department of Pharmaceutics, Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China. tangzhan1986@126.com
- Publication Type:Journal Article
- MeSH:
Administration, Cutaneous;
Animals;
Chemistry, Pharmaceutical;
Gels;
In Vitro Techniques;
Male;
Permeability;
Pyrazines;
administration & dosage;
chemistry;
pharmacokinetics;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Chinese Materia Medica
2013;38(13):2101-2104
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study was to prepare tetramethylpyrazine hydrochloride transdermal gel and to study its permeation ability in vitro. The skin permeation ability was evaluated by Valian-Chien permeation cells with isolated rat skin. The concentration of tetramethylpyrazine in samples was determined by HPLC. The optimal formulation was composed with 5% azone, 5% peppermint oil, 8% sodium carboxymethylcellulose and 8% tetramethylpyrazine hydrochloride. The accumulative permeation amount of the gel was (6 731.87 +/- 102.31) microg x cm(-2) in 12 h,and the permeation rate was (535.02 +/- 33.89) microg x cm(-2) x h(-1). The release profile in vitro was in line with zero-order formulation. Tetramethylpyrazine hydrochloride gel prepared in the study would be developed as a novel transdermal preparation.
