Preventive effect of ganlong capsule on chronic alcoholic hepatic injury in rats.
- Author:
Xu-Qiang ZHANG
1
;
Hong-Bing WU
;
Li PENG
;
Xiao-Min GONG
;
Jiao LI
;
Xiao-Fei PU
;
Fang PENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Chronic Disease; Female; Glutathione; metabolism; Liver; pathology; Liver Diseases, Alcoholic; metabolism; pathology; prevention & control; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; blood
- From: China Journal of Chinese Materia Medica 2013;38(13):2197-2201
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preventive effect of Ganlong capsule on chronic alcoholic hepatic injury in rats and its mechanism.
METHODThe rat chronic hepatic injury model was induced by intragastrically administered with gradient alcohol, once a day for 12 weeks. Efforts were made to detect the content of ALT, AST, TG, CHO, TNF-alpha in rat serum and GSH, SOD, MDA, ADH, Alb in hepatic tissues were detected, conduct a hepatic pathological examination, and pathological injury grading for livers.
RESULTGanlong capsule could reduce the content of ALT, AST, TG in blood serum, MDA in hepatic tissues (P < 0.05), and enhance the activities of antioxidants such as SOD and GSH in hepatic tissues (P < 0.05). According to the liver histopathological observation, most structures of hepatic lobules in the model group were destroyed, with disordered liver cell cords, diffuse fat empty bubbles of different sizes in cytoplasm, focal necrosis and infiltration of inflammatory cells. All of treatment groups showed alleviation in rat liver injury to varying degrees.
CONCLUSIONGanlong capsule has a significant preventive effect to chronic alcoholic hepatic injury in rats.
