Pharmacokinetics of photosensitizer m-THPC in rat models of liver cancer via orthotropic implantation using Walker-256.
- Author:
Jian-dong WANG
1
;
Zhi-wei QUAN
;
Jun SHEN
;
Xue-ping ZHOU
;
Fang-hong LUO
;
Sheng-yu WANG
;
Jiang-hua YAN
;
Dong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Liver Neoplasms, Experimental; metabolism; Male; Neoplasm Transplantation; Organophosphorus Compounds; pharmacokinetics; Photosensitizing Agents; pharmacokinetics; Rats; Rats, Wistar; Tissue Distribution
- From: Chinese Journal of Surgery 2011;49(4):341-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pharmacokinetics, distribution and excretion of m-THPC in rat models of liver cancer via orthotropic implantation using Walker-256.
METHODSAfter an intravenous injection of m-THPC with 0.3 mg/kg, the concentrations of m-THPC in biological specimens were determined by a fluorescence method. The data obtained were processed with PK-GRAPH pharmacokinetic procedure.
RESULTSThe disposition of m-THPC in rat models of liver cancer Walker-256 was conformed to a two compartment model with T(1/2)α = 1.18 h, T(1/2)β = 22.57 h at the dose of 0.3 mg/kg.m-THPC was shown to be widely distributed to the various tissues. There was a highest drug accumulation in liver and liver cancer, and lowest in skin and muscle. Ratio of m-THPC concentration in the Walker-256 tumor compared to normal tissue reach the peak 24 h after m-THPC administration.
CONCLUSIONSm-THPC is distributed widely and eliminated at a rapid rate in Walker-256 rats. Twenty four hours after m-THPC administration may be the best time for photodynamic therapy of liver cancer.
