Rhus coriaria L. increases serum apolipoprotein-A1 and high-density lipoprotein cholesterol levels: a double-blind placebo-controlled randomized clinical trial.

Zahra Hajmohammadi; Mojtaba Heydari; Majid Nimrouzi; Pouya Faridi; Mohammad Javad Zibaeenezhad; Gholamhossein Ranjbar Omrani; Mesbah Shams

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Rhus coriaria L. increases serum apolipoprotein-A1 and high-density lipoprotein cholesterol levels: a double-blind placebo-controlled randomized clinical trial.

Author: Zahra HAJMOHAMMADI ¹ ; Mojtaba HEYDARI ¹ ; Majid NIMROUZI ² ; Pouya FARIDI ³ ; Mohammad Javad ZIBAEENEZHAD ⁴ ; Gholamhossein Ranjbar OMRANI ⁵ ; Mesbah SHAMS ⁶
Author Information

1. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz 98713, Iran.
2. Department of Traditional Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz 98713, Iran.
3. Department of Phytopharmaceuticals, School of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz 98713, Iran.
4. Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz 98713, Iran.
5. Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz 98713, Iran.
6. Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz 98713, Iran. Electronic address: shams@sums.ac.ir.
Publication Type:Journal Article
Keywords: Apolipoproteins A; Dietary supplements; Double-blind method; Dyslipidemias; Lipids; Plants; Randomized controlled trial; Rhus coriaria L.
From: Journal of Integrative Medicine 2018;16(1):45-50
CountryChina
Language:English
Abstract:
BACKGROUNDLipid-lowering effect of Rhus coriaria L. (Rhus) has been investigated in multiple animal studies with promising results. Nonetheless, its clinical efficacy has not been adequately examined.
OBJECTIVEThe aim of this study was to evaluate the lipid-lowering effects of Rhus among patients with hyperlipidemia.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONSThe study was designed as a two-arm, double-blind placebo-controlled randomized clinical trial, using a parallel design. Eighty patients with primary hyperlipidemia were randomly assigned to receive Rhus capsules or placebo for 6 weeks.
MAIN OUTCOME MEASURESThe serum lipid levels, apolipoprotein-A1 (Apo-A1) and apolipoprotein-B (Apo-B) were measured.
RESULTSMean serum high-density lipoprotein cholesterol (HDL-C) and Apo-A1 levels were significantly increased in the Rhus group, compared with the placebo group, after 6 weeks of intervention (P = 0.001). The analysis of covariance test including age, gender, body mass index (BMI), and smoking as co-variables revealed that the increase in HDL-C and Apo-A1 levels remained significant, and increases in HDL-C were dependent on the increase in Apo-A1 levels. No significant difference was observed between Rhus and placebo groups in terms of mean reductions in total cholesterol, low-density lipoprotein cholesterol and triglyceride levels; however, more significant improvement was observed among obese patients (BMI ≥ 30 kg/m).
CONCLUSIONThe study showed significant increases in HDL-C and Apo-A1 levels in response to Rhus supplementation in patients with hyperlipidemia.
TRIAL REGISTRATIONClinicalTrials.gov ID: NCT02295293.