Association of ORMDL3 single nucleotide polymorphisms with lysophosphatidylcholine and apolipoprotein B levels in children with asthma.
- Author:
Bing-Jie WANG
1
;
Gui-Lan WANG
;
De-Hui CHEN
;
Wen-Xiang WANG
;
Juan HUANG
;
Jia-Yan RONG
;
Xiang-Teng LIU
;
Sai YANG
Author Information
- Publication Type:Journal Article
- MeSH: Apolipoproteins B; blood; Asthma; blood; genetics; Child; Child, Preschool; Female; Humans; Lysophosphatidylcholines; blood; Male; Membrane Proteins; genetics; Polymorphism, Single Nucleotide
- From: Chinese Journal of Contemporary Pediatrics 2015;17(3):241-244
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association of ORMDL3 single nucleotide polymorphisms (SNP) with lysophosphatidylcholine (LysoPC) and apolipoprotein B (apoB) levels.
METHODSA total of 300 children diagnosed with bronchial asthma between January 2010 and December 2012 were selected for the asthma group, and 298 children diagnosed with upper respiratory tract infection in the same period were selected for the control group. Serum LysoPC and apoB levels were measured using enzyme-linked immunosorbent assay. Genotype analysis was performed using the TaqMan probe.
RESULTSLysoPC and apoB levels were significantly higher in the asthma group than in the control group (P<0.01). Among children with various genotypes of ORMDL3 gene at locus rs12603332, the asthma group had significantly higher LysoPC and apoB levels than the control group (P<0.01). Among the children with asthma, those with CC genotype had significantly higher LysoPC and apoB levels than those with CT and TT genotypes (P<0.01).
CONCLUSIONSLysoPC and apoB may intervene in the pathological process of asthma. Pro-inflammatory gene ORMDL3 SNP rs12603332 may be associated with high LysoPC and apoB levels, which leads to the occurrence of childhood asthma.
