The evaluation of cytocompatibility of mesenchymal stem cells on random biopolyster scaffolds.
- Author:
Xiujie TANG
1
;
Ping HU
;
Qingyu WU
Author Information
1. Department of Cardiovascular Disease, First Hospital of Tsinghua University, Beijing 100016, China.
- Publication Type:Journal Article
- MeSH:
Absorbable Implants;
Animals;
Biocompatible Materials;
chemistry;
Butylene Glycols;
chemistry;
Cell Adhesion;
Cells, Cultured;
Male;
Materials Testing;
Mesenchymal Stromal Cells;
cytology;
Polyesters;
chemistry;
Polymers;
chemistry;
Rabbits;
Tissue Engineering;
methods;
Tissue Scaffolds
- From:
Journal of Biomedical Engineering
2007;24(4):790-793
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSCs) were isolated from the bone marrow of rabbits and inoculated respectively on 3D scaffolds of poly (3-Hydroxybutyrate-co-3-Hydroxyvalerate) (PHBV), poly (butylenes succinate) (PBS) and the blends for evaluation of their cytocompatibilities in vitro. It was found that the blends of less microporous possessed the best performance on attachment and proliferation of MSCs in the six configurations. The toluiding blue staining showed the best morphology of mensenchymal stem cells (MSCs) on the blends of less microporous blends. The scanning electronic microscopy (SEM) results showed that the blends of less microporous blends had the appropriate roughness for MSCs to attach and proliferate, which can be used as a suitable biomaterial to create small caliber vascular grafts.
