BACKGROUNDTo evaluate the clinical effect and toxicity of NVB and DDP combination chemotherapy in the treatment of advanced non-small cell lung cancer.

METHODSAll 52 patients were treated with NP regimen: NVB 25 mg/m² iv, D1, D8; DDP 80 mg/m² iv, D1. The regimen was repeated every 3 weeks, tumor assessment was done after 2 cycles.

RESULTSThere were 2 complete responses (CR) and 26 partial responses (PR). The overall responses rate (CR+PR) was 53.8%, and the main toxicity was leucopenia, nause, vomiting and phlebitis.

CONCLUSIONSThe NP regimen is effective in the treatment of advanced non-small cell lung cancer, the toxicity is well tolerated. Hence the regimen can be regarded as first-line regimen of advanced non-small cell lung cancer.