Relationship between the expression of E-cadherin and MVD and its significance in lung cancer.
- Author:
Xinyun WANG
1
;
Juhong YANG
;
Ying MA
;
Bo CHENG
;
Hongwei ZHENG
;
Haiyan ZHENG
;
Congzhong ZHU
;
Ting LIU
;
Yan LI
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Lung Cancer 2003;6(6):477-479
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo study the relationship between the expression of E-cadherin and MVD in lung cancer and its significance.
METHODSThe expressions of E-cadherin and factor VIII were detected in 104 lung cancer tissues by immunohistochemical method, and MVD was calculated by image analysis system.
RESULTSThe expression of E-cadherin was significantly related to the differentiation of lung cancer (P < 0.05). A negative correlation was observed between E-cadherin expression and MVD in lung cancer tissues (P= 0.047).
CONCLUSIONSDownexpression of E-cadherin and increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.
