Research progress in cytokines and signaling pathways for promoting pulmonary angiogenesis and vascular development.
- Author:
Xing-Na MA
1
;
Qiu-Ping LI
;
Zhi-Chun FENG
Author Information
1. Department of Neonatal Intensive Care Unit, Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command of People's Liberation Army, Beijing 100007, China. zhuifengma21@163.com.
- Publication Type:Journal Article
- MeSH:
Angiopoietins;
physiology;
Blood Vessels;
embryology;
Bronchopulmonary Dysplasia;
etiology;
Cytokines;
physiology;
Ephrins;
physiology;
Humans;
Infant, Newborn;
Lung;
blood supply;
Neovascularization, Physiologic;
Receptors, Notch;
physiology;
Signal Transduction;
physiology;
Vascular Endothelial Growth Factor A;
physiology
- From:
Chinese Journal of Contemporary Pediatrics
2013;15(9):800-805
- CountryChina
- Language:Chinese
-
Abstract:
With the advances in pre- and post-natal medical care, the incidence of bronchopulmonary dysplasia (BPD) is on the rise, while its pathogenesis remains not clear. New BPD theory shows that the core pathogenesis of BPD is simple alveolar structure and pulmonary microvascular abnormalities that eventually lead to reduced pulmonary gas exchange, so the research on pulmonary microvascular development was gradually taken seriously. Pulmonary angiogenesis and vascular development require the participation of various cytokines and signaling pathways, the most important of which include VEGF/VEGFR pathway, Ang/Tie pathway, Ephrins/Eph pathway, and Notch/Jagged1 pathway. These cytokines and signaling pathways play important roles in pulmonary vascular development.
