Association between vitamin D receptor gene polymorphisms and pediatric Crohn's disease in China: a study based on gene sequencing.
- Author:
You-You LUO
1
;
Xiao-Li SHU
;
Hong ZHAO
;
Jin-Dan YU
;
Ming MA
;
Jie CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Calcifediol; blood; Child; Child, Preschool; Crohn Disease; blood; genetics; Female; Humans; Male; Polymorphism, Single Nucleotide; Receptors, Calcitriol; genetics; Sequence Analysis, DNA
- From: Chinese Journal of Contemporary Pediatrics 2013;15(11):1006-1008
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between TaqI, BsmI, and ApaI polymorphisms of vitamin D receptor (VDR) gene and pediatric Crohn's disease (CD) in China.
METHODSNineteen children with CD were selected as a case group, and 122 healthy children who underwent physical examination were selected as a control group. Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured using ELISA. The TaqI, BsmI, and ApaI polymorphisms of VDR gene were determined by gene sequencing, and the two groups were compared in terms of genotype and allele frequencies.
RESULTSThe case group had significantly lower serum 25(OH)D3 levels than the control group (17.3±2.4 ng/mL vs 26.9±2.1 ng/mL; P<0.05). There were no significant differences in the frequencies of genotypes and alleles of TaqI, BsmI, and ApaI polymorphisms between the case and control groups (P>0.05).
CONCLUSIONSChildren with CD have low serum 25(OH)D3 levels. TaqI, BsmI, and ApaI polymorphisms of VDR gene may not be associated with susceptibility to CD among the Chinese population.
