Changes in Th17 and CD4+CD25+ Treg cells and their significance among children with hand, foot and mouth disease.
- Author:
Tao JIANG
1
;
Shuang-Jie LI
;
Wen-Xian OUYANG
;
Yan-Fang TAN
;
Fu-Rong LIU
;
Geng-Ji XIAO
;
Lian TANG
;
Hui ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Hand, Foot and Mouth Disease; immunology; Humans; Infant; Interleukin-10; blood; Interleukin-17; blood; T-Lymphocytes, Regulatory; immunology; Th17 Cells; immunology; Transforming Growth Factor beta; blood
- From: Chinese Journal of Contemporary Pediatrics 2013;15(12):1113-1115
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in peripheral blood Th17 and CD4(+)CD25(+) regulatory T (Treg) cells and their significance among children with hand, foot and mouth disease (HFMD).
METHODSEighty-nine children with HFMD, including 55 cases of common HFMD and 34 cases of severe HFMD, were included in the study; and 30 healthy children were selected as the control group. The percentages of Th17 and CD4(+)CD25(+) Treg cells in CD4(+) T cells in peripheral blood were determined by flow cytometry. The expression levels of interleukin (IL)-10, transforming growth factor-β (TGF-β), and IL-17 were measured by enzyme-linked immunosorbent assay.
RESULTSCompared with the control group, the cases of common HFMD and severe HFMD had significantly increased levels of Th17 cells and IL-17 (P<0.05) but significantly decreased levels of CD4(+)CD25(+) Treg cells, IL-10, and TGF-β (P<0.05). The severity of the HFMD was positively correlated with the levels of Th17 cells and IL-17 in peripheral blood but negatively correlated with the levels of CD4(+)CD25(+) Treg cells, IL-10, and TGF-β.
CONCLUSIONSChildren with HFMD have increased response of Th17 cells but decreased response of CD4(+)CD25(+) Treg cells in peripheral blood. Th17/CD4(+)CD25(+) Treg cell imbalance may play an important role in the pathogenesis of HFMD.
