Changes in T lymphocyte subsets in preterm infants with intrauterine growth retardation.
- Author:
Hua-Bao PENG
1
;
Zhang-Hua HOU
;
Wei LONG
;
Ruo-Kun TAN
;
Li-Wei TANG
Author Information
- Publication Type:Journal Article
- MeSH: Female; Fetal Growth Retardation; immunology; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; T-Lymphocyte Subsets; immunology
- From: Chinese Journal of Contemporary Pediatrics 2014;16(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study changes in T lymphocyte subsets in preterm infants with intrauterine growth retardation (IUGR).
METHODSThe study enrolled 29 IUGR preterm infants, 38 preterm infants born appropriate for gestational age (AGA), and 20 healthy full-term infants. Peripheral blood was sampled during the first 24 hours of life, and again at a corrected age of 38 weeks of the preterm infants. T lymphocyte subsets were analyzed by flow cytometry, and absolute counts of leukocytes, total lymphocytes, and T lymphocytes were determined with an automated hematology analyzer.
RESULTSWithin the first 24 hours of life, percentages of CD3(+) and CD4(+) were lower in IUGR preterm infants than in AGA preterm infants and full-term infants (P<0.05), percentages of CD8(+) and CD4(+)/CD8(+) ratio were lower in IUGR preterm infants than in full-term infants (P<0.05), and percentages of CD3(+), CD4(+) and CD4(+)/CD8(+) ratio were lower in AGA preterm infants than in full-term infants (P<0.05). Moreover, the absolute counts of total lymphocytes were lower in IUGR preterm infants than in full-term infants (P<0.05); the absolute counts of T lymphocytes were lower in preterm infants, regardless of IUGR, than in full-term infants (P<0.05), and lower in IUGR infants than in AGA infants (P<0.05). At the corrected age of 38 weeks, percentages of CD3(+), CD4(+) and CD4(+)/CD8(+) ratio were increased in both IUGR and AGA infants as compared to the measurements within the first 24 hours of life (P<0.05), and percentages of CD3(+), CD4(+), CD8(+) and CD4(+)/CD8(+) ratio were lower in IUGR infants than in AGA infants (P<0.05), whereas there were no significant differences in counts of leukocytes, total lymphocytes and T lymphocytes between IUGR and AGA infants (P>0.05).
CONCLUSIONSThere may be a certain degree of compromise in cell-mediated immunity in preterm infants with IUGR and this compromise may last to 38 weeks after birth.