Serious systemic adverse events associated with allergen-specific immunotherapy in children with asthma.
- Author:
Li DAI
1
;
Ying HUANG
;
Ying WANG
;
Huan-Li HAN
;
Qu-Bei LI
;
Yong-Hui JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Animals; Asthma; physiopathology; therapy; Child; Child, Preschool; Desensitization, Immunologic; adverse effects; Female; Humans; Male; Peak Expiratory Flow Rate; Pyroglyphidae; immunology; Retrospective Studies; Vaccines; adverse effects
- From: Chinese Journal of Contemporary Pediatrics 2014;16(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo retrospectively assess serious systemic adverse effects of standardized dust-mite vaccine in children with asthma.
METHODSMedical records of 704 children (5-17 years in age) with asthma between January, 2005 and December, 2011 were reviewed. Serious systemic adverse events following treatment with a standardized dust-mite vaccine in these children were analyzed.
RESULTSA total of 336 systemic adverse reactions were observed in 17.0% (120/704) of the patients analyzed of these adverse reactions, 18 (5.4%) were serious (level 3), 318 (94.6%) were not serious (below level 3), and no single case of anaphylactic shock (level 4) was recorded. Systemic adverse events occurred most frequently in the 5 to 11-year age group and in the summer season (from June to August). In the 18 severe cases, the peak expiratory flow (PEF) dropped by 20% immediately after the vaccine injection, and other major clinical symptoms included cough, wheezing and urticaria. All children with serious systemic adverse effects were given inhaled hormone and atomized short-acting beta agonists, oral antihistamines, intravenous dexamethasone and/or intramuscular adrenaline. After these treatments, the clinical symptoms were significantly relieved.
CONCLUSIONSThe rate of serious systemic adverse events following allergen-specific immunotherapy is relatively low in children with allergic asthma. Conventional medications are effective in managing these immunotherapy-associated adverse events.