Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs.
- Author:
Qi MA
1
;
Li WANG
;
Hua YAO
;
Jun ZHU
;
Shuxia WANG
;
Xhaoxia ZHANG
;
Tingting WANG
;
Yan MA
;
Yinxia SU
;
Zhiqiang WANG
;
Lili DING
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; genetics; China; ethnology; Cholesterol; blood; Diabetes Mellitus, Type 2; blood; etiology; genetics; Genotype; Humans; Logistic Models; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2016;33(4):540-544
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China.
METHODSOne thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system.
RESULTSThe distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups (P>0.05). After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model (OR=1.181, 95%CI: 1.021-1.366, P=0.025; OR=1.296, 95%CI: 1.043-1.610, P=0.019). The total cholesterol level was higher in AA carriers than GG and GA carriers (P<0.05).
CONCLUSIONThe AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.
