Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan.

Chang Tan; Lulin Huang; Zhenglin Yang

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Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan.

Author: Chang TAN ^{1
,

2} ; Lulin HUANG ; Zhenglin YANG
Author Information

1. Southwestern Medical University, Luzhou, Sichuan 646000, China
2. Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610000, China. Email: zliny@yahoo.com.
Publication Type:Journal Article
MeSH: Carrier Proteins; genetics; China; ethnology; Collagen Type XI; genetics; Female; Glaucoma, Angle-Closure; genetics; Humans; Male; Polymorphism, Single Nucleotide; Protein D-Aspartate-L-Isoaspartate Methyltransferase; genetics
From: Chinese Journal of Medical Genetics 2016;33(4):545-549
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo assess the association of single nucleotide polymorphisms (SNPs) of PLEKHA7, COL11A1 and PCMTD1-ST18 genes and primary angle closure glaucoma (PACG) among ethnic Han Chinese from Sichuan Province.
METHODSIn this study, 362 subjects with PACG and 1056 age- and sex-matched healthy controls were recruited. Genotypes of 3 reported SNPs, including PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 were determined with a SNaPshot method.
RESULTSThe P values for the genotype frequencies of rs11024102, rs3753841 and rs1015213 between the patient and control groups were 0.62 (OR=1.09, 95%CI: 0.91-1.30), 0.42 (OR=1.04, 95%CI: 0.87-1.41) and 0.34 (OR=1.35, 95%CI: 0.73-2.49), respectively. And the P values for the allele frequency distributions of PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 between the two groups were 0.347, 0.698 and 0.344, respectively.
CONCLUSIONNo significant association of PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 with PACG was found among ethnic Han Chinese from Sichuan.