Advance in research on the function of telomeric shelterin component TPP1 and its relationship with characteristics of tumors.
10.3760/cma.j.issn.1003-9406.2016.04.033
- Author:
Lihua YAO
1
;
Xiaolan GUO
Author Information
1. Department of Laboratory Medicine, Translational Medicine Research Center, North Sichuan Medical College, Nanchong, Sichuan 637000, China. Email: alan5200@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Chromosomal Instability;
DNA Damage;
Humans;
Neoplasms;
genetics;
Telomere;
Telomere-Binding Proteins;
chemistry;
physiology
- From:
Chinese Journal of Medical Genetics
2016;33(4):573-577
- CountryChina
- Language:Chinese
-
Abstract:
As an important telomere binding protein, TPP1 protects the ends of telomeres and maintains the stability and integrity of its structure and function by interacting with other five essential core proteins (POT1, TRF1, TRF2, TIN2, and RAP1) to form a complex called Shelterin. Recently, researchers have discovered that TPP1 participates in protection of telomeres and regulation of telomerase activity. The relationship between TPP1 and tumorigenesis, tumor progression and treatment has also been investigated. This paper reviews the latest findings of TPP1 regarding to its structure, function and interaction with other proteins involved in tumorigenesis.
