Correlation of cytogenetic changes with VEGF and TRacp-5b levels among 60 elderly patients with multiple myeloma.
- Author:
Ling CEN
1
;
Yu JIANG
;
Xiuwen ZHANG
;
Hongying CHAO
;
Rong XIAO
;
Wenmin HAN
;
Tao CHEN
;
Xuzhang LU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Chromosome Aberrations; Cytogenetic Analysis; Female; Humans; In Situ Hybridization, Fluorescence; Karyotype; Male; Multiple Myeloma; blood; diagnosis; genetics; Tartrate-Resistant Acid Phosphatase; blood; Vascular Endothelial Growth Factor A; blood
- From: Chinese Journal of Medical Genetics 2016;33(5):602-605
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the correlation of cytogenetic changes with serum vascular endothelial growth factor (VEGF) and serum tartrate resistant acid phosphatase (TRacp-5b) levels among elderly patients with multiple myeloma (MM).
METHODSChromosomal changes were analyzed with a modified culturing method in the presence of IL-6. Serum levels of VEGF and TRacp-5b were determined with enzyme-linked immunosorbent assays (ELISA).
RESULTSAmong the 60 MM patients, chromosomal abnormalities were found in 27 cases, including 22 with numerical abnormalities and 15 with structural abnormalities. Many patients had both numerical and structural abnormalities. For 33 patients with a normal karyotype, the levels of VEGF and TRacp-5b were 117.35 ± 55.26 pg/mL and 4.15 ± 2.15 U/L, respectively, while for 27 patients with an abnormal karyotype, the levels of VEGF and TRacp-5b were 190.26 ± 85.74 pg/ml and 5.96 ± 2.24 U/L, respectively. The difference between the two groups was significant (P<0.05).
CONCLUSIONCompared with MM patients with a normal karyotype, the levels of VEGF and TRacp-5b are higher in those with cytogenetic abnormalities.
