Advance in research on the genetic etiology of spontaneous intracerebral hemorrhage.
10.3760/cma.j.issn.1003-9406.2016.05.028
- VernacularTitle:自发性脑出血遗传学病因的研究进展
- Author:
Jifeng KANG
1
;
Qing HUANG
;
Yunhai LIU
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Email: xyneuro@126.com.
- Publication Type:Journal Article
- MeSH:
Biomedical Research;
methods;
trends;
Cerebral Hemorrhage;
diagnosis;
genetics;
Genetic Predisposition to Disease;
genetics;
Genetic Variation;
Genotype;
Humans;
Mutation;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Medical Genetics
2016;33(5):702-707
- CountryChina
- Language:Chinese
-
Abstract:
Spontaneous intracerebral hemorrhage (SICH) is a form of brain parenchymal hemorrhage caused by a variety of non-traumatic reasons, resulting in cerebral artery, veins or capillaries rupture. The etiology of SICH is variable, with hypertensive intracerebral hemorrhage being the most common, accounting for 60% ~ 81% of all cases. Cerebral amyloid angiopathy, drug use related hemorrhage, Moyamoya disease are also important causes of SICH. Previous studies showed that genetic factors play an important role in the pathogenesis of SICH. Here the genetic mechanisms of SICH and classification of its etiology are reviewed.
