Association of LMP gene polymorphisms with chronic HCV infection among ethnic Han population from Yunnan.
- Author:
Tong LI
1
;
Chengxiu LIU
;
Yufeng YAO
;
Jiankun YU
;
Li SHI
;
Yunsong SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; genetics; Genetic Predisposition to Disease; genetics; Haplotypes; genetics; Hepatitis C; genetics; Humans; Male; Peptides; genetics; Polymorphism, Single Nucleotide; genetics
- From: Chinese Journal of Medical Genetics 2016;33(6):806-810
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of single nucleotide polymorphisms (SNPs) of the low molecular weight polypeptide (LMP) gene with chronic hepatitis C virus (HCV) infection among ethnic Han population from Yunnan.
METHODSA total of 427 patients with chronic HCV infection and 412 healthy controls were recruited. SNPs rs1351383, rs17587 and rs2127675 from the promoter region of the LMP2 gene and rs2071543 from the promoter region of the LPM7 gene were genotyped using a TaqMan probe. The haplotypes were constructed. Frequencies of various alleles, genotypes and haplotypes of the selected SNPs were calculated, and their association with chronic HCV infection was analyzed.
RESULTSThe frequencies of rs1351383 and rs2127675 alleles of the LMP2 gene, as well as the A-G-A and C-G-G haplotypes of the rs1351383/rs17587/rs2127675 loci, had differed significantly between the two groups (P<0.05).
CONCLUSIONThe C allele of the rs1351383 locus and G allele of the rs2217675 locus of the LMP2 gene may be susceptible factors for chronic HCV infection among ethnic Han people from Yunnan. The A-G-A haplotype of the rs1351383/rs17587/rs2127675 loci may confer a protective effect, while the C-G-G haplotype may be a susceptible factor for chronic HCV infection in this population.
