Influence of chromosomal polymorphisms on the clinical outcome of patients undergoing in vitro fertilization embryo transfer.
- Author:
Yumei LI
1
;
Donge LIU
;
Zhongyuan YAO
;
Lingqian WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromosome Aberrations; Chromosomes; genetics; Embryo Transfer; methods; Female; Fertilization in Vitro; methods; Humans; Male; Polymorphism, Genetic; genetics; Pregnancy; Pregnancy Outcome
- From: Chinese Journal of Medical Genetics 2016;33(6):849-853
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of chromosome polymorphisms on the outcome of in vitro fertilization embryo transfer (IVF-ET).
METHODSPatients who completed the first cycle of in vitro fertilization fresh embryo transfer were retrospective studied. Patients with the chromosome polymorphisms were classified as to the study group (200 treatment cycles), all patients with normal chromosomes at the same period were classified as the control group (4777 treatment cycles).
RESULTSNo significant difference was found between the chromosome polymorphisms and the control groups in terms of clinical pregnancy rate (44.50% vs. 39.85%, P=0.750), early abortion rate (15.73% vs. 10.79%, P=0.163) and live birth rate per cycle (34.5% vs. 30.73%, P=0.437) except for fertilization rate (60.94% vs. 64.08%, P=0.001), cleavage rate (95.01% vs. 97.09%, P=0.000) and good quality embryo rate (53.8% vs. 58.2%, P=0.001).
CONCLUSIONChromosomal polymorphisms appeared to have no adverse influence on the outcome of IVF-ET treatment.
