Progress on establishment of animal model of osteoarthritis by intra-articular injection.
- Author:
Yu-feng MA
;
Yin-ze QI
;
Qing-fu WANG
;
Zhao-jun CHEN
;
Dong YU
;
Hao-yun ZHENG
;
Ji WU
;
Yue-shan YIN
;
Qing-xue QI
- Publication Type:Journal Article
- MeSH:
Animals;
Cytokines;
analysis;
Disease Models, Animal;
Injections, Intra-Articular;
Mice;
Osteoarthritis;
diagnosis;
etiology;
immunology;
Rabbits;
Rats
- From:
China Journal of Orthopaedics and Traumatology
2015;28(1):90-95
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (Osteoarthritis, OA) is a common clinical degenerative joint disease with increased incidence rate in recent years. Animal experiment is one of the important ways to explore pathogenesis and treatment of OA, while induced animal model is the most important part in animal experiment. Intra-articular injection of drugs is a classical method for establishing animal model of OA. Choose of animal should follows the principle of correlation, appropriateness and practicability, injections should perform in accordance with experimental purposes and subject, detections means and evaluation methods also should corresponding to experimental reality. The gold standard of OA animal model and intra-articular injections has not build, need further study.
