Analysis of prognostic factors in gastrointestinal stromal tumors of the small intestine.
- Author:
Yue-kui BAI
1
;
Yong-fu SHAO
;
Su-sheng SHI
;
Yan-ning GAO
;
Yun-tian SUN
;
Yu-liang WAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Gastrointestinal Stromal Tumors; diagnosis; pathology; Humans; Immunohistochemistry; Intestinal Neoplasms; diagnosis; pathology; Intestine, Small; pathology; Male; Middle Aged; Prognosis
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the prognostic factors in patients with gastrointestinal stromal tumors of the small intestine.
METHODSTumor slides stained with hematoxylin and eosin from these patients were reviewed. Two histomorphologically representative areas were identified and arrayed on a tissue microarray. Immunohistochemistry staining were performed using antibodies to detect the expression of c-kit protein (CD117), CD34, smooth muscle actin, desmin, S-100, Ki-67, P53 and bcl-2 protein. The relationship between clinicopathologic features and prognosis was analyzed by univariate analysis.
RESULTSThe 1-, 3-, 5-year survival rate of 58 such patients were 98.3%, 69.7%, and 50.9% respectively. The prognosis was related with tumor size and gender by univariate analysis (P< 0.05).
CONCLUSIONMore attention should be paid to the male patients with small intestine stromal tumors,especially those with tumors size> 5 cm, because those tumors are more likely to metastasize than smaller tumors (< or = 5 cm).
