Growth hormone receptor expression in human colorectal cancer and its implication.
- Author:
Xiao-dong YANG
1
;
Fu-kun LIU
;
Zhe XU
;
Jie-shou LI
Author Information
- Publication Type:Journal Article
- MeSH: Colorectal Neoplasms; metabolism; pathology; Female; Gene Expression; Humans; Immunohistochemistry; Male; Middle Aged; Receptors, Somatotropin; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(3):252-254
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of the expression of growth hormone receptor (GHR) in the development and progression of human colorectal cancer (CRC).
METHODSThe expression levels of GHR and Ki-67 were detected by immunohistochemistry technique in CRC specimens and normal mucous tissue from 100 patients with CRC. The association between expression of GHR and clinicopathological factors was analyzed.
RESULTSThe expression of GHR was higher in the colorectal cancerous tissue compared to the normal mucous tissue (81% vs. 68%). The expression of GHR was significantly correlated with pathological staging (P=0.047), tumor differentiation (P=0.003) and tumor size (P=0.017). The expression of GHR was significantly associated with the expression of Ki-67 (P< 0.01) as well as tumor proliferation (P< 0.01).
CONCLUSIONThe over-expression of GHR is shown in human colorectal cancer and it also plays an important role in the development of human colorectal cancer. The use of rhGH in clinic should be cautious.
