Analysis of the clinicopathological features of Chinese hereditary nonpolyposis colorectal cancer.
- Author:
Hei-ying JIN
1
;
Long CUI
;
Yi-jiang DING
;
Yu-ti YAN
;
Rong-gui MENG
;
Fei LIU
;
Xiao-chun ZHANG
;
De-hong YU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; China; epidemiology; Colorectal Neoplasms, Hereditary Nonpolyposis; epidemiology; genetics; pathology; Female; Humans; Incidence; Male; Middle Aged; Prognosis; Survival Rate; Young Adult
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(4):316-318
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathological features of Chinese hereditary nonpolyposis colorectal cancer (HNPCC).
METHODSPatients who met the Amsterdam criteria were enrolled in this study from several hospitals in China. Clinicopathological features of patients with HNPCC were compared between the patients with suspected HNPCC and sporadic colorectal cancer.
RESULTSOne hundred and sixty-seven individuals from 31 families met the Amsterdam criteria. The average age was 48.6 (22-78) years old. There were 43 cases (31.9%) with ascending colon cancer and 52 cases (38.5%) with rectal cancer. The 3-, 5-, 10- years survival rate was 70.3%, 49.9% and 39.7% respectively. The incidence of multiple primary neoplasms was 20.4% .
CONCLUSIONSChinese HNPCC is characterized by early disease onset. Rectal cancer and ascending colon cancer are the first and the secondly common cancer for Chinese HNPCC. Gastric cancer is the most common parenteral cancer in Chinese HNPCC families.
