Relationship between cyclooxygenase- 2 expression and angiogenesis in patients with gastric cancer.
- Author:
Wei-hao SUN
1
;
Yun-liang SUN
;
Ren-nian FANG
;
Xi-long OU
;
Qi-ping XUE
;
Yun SHAO
;
Hai-chen XU
;
Yun-lin CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Cyclooxygenase 2; metabolism; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; metabolism; pathology; Stomach Neoplasms; metabolism; pathology
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(4):343-347
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate COX-2 expression in patients with gastric cancer and its relationship with angiogenesis and clinicopathologic features of gastric cancer.
METHODSCOX-2 expression and CD34-stained microvessel density (MVD) were detected by immunohistochemical methods in specimens from 96 patients with gastric cancer. The correlations among COX-2 expression, MVD and clinicopathologic features were analyzed.
RESULTSThe COX-2 positive rate and MVD in gastric cancer were significantly higher than those in the normal gastric mucosa (80.2% vs. 13.3%; 32.5+/- 8.3 vs. 13.1+/- 2.4, all P< 0.01). The COX-2 positive rate and MVD in the patients with stage III and IV were significantly higher (91.4% and 34.9+/- 8.7 respectively, P< 0.01), than that in the patients with stage I and II. The COX-2 positive rate and MVD in the cases with lymph node metastasis were 87.9% and (35.0+/- 8.5) respectively, higher than those in the cases without lymph node metastasis (P< 0.05). The Spearman rank correlation test showed a significant correlation between COX-2 expression and tumor MVD (r=0.311, P< 0.01).
CONCLUSIONSCOX-2 plays an important role in gastric cancer angiogenesis. COX-2 and angiogenesis induced by COX-2 contribute to tumor invasion and lymph node metastasis.
