COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis.
- Author:
Jun ZHANG
1
;
Jun JI
;
Fei YUAN
;
Chao YAN
;
Ying-yan YU
;
Bing-ya LIU
;
Zheng-gang ZHU
;
Hao-ran YIN
;
Yan-zhen LIN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Cyclooxygenase 2; metabolism; Female; Humans; Lymph Nodes; metabolism; pathology; Lymphangiogenesis; Lymphatic Metastasis; Male; Middle Aged; Stomach Neoplasms; metabolism; pathology; Vascular Endothelial Growth Factor C; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(4):348-351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-C (VEGF-C) in human gastric cancer, the relationship between their expression and the clinicopathological features,as well as the relationship between these two parameter expression and lymphangiogenesis and lymph node metastasis.
METHODSCOX-2 and VEGF-C expressions were detected in 63 gastric cancer samples by immunostaining. Lymphangiogenesis was evaluated by immunostaining with the specific antibody LYVE-1.
RESULTSThe expression rates of COX-2 and VEGF-C were 66.7% (42/63), 52.4% (33/63), respectively in 63 gastric cancer specimens. LYVE-1 was positive in 35 cases (35/63), which indicated lymphangiogenesis in the tumors. The expression of COX-2 was significantly correlated with the expression of VEGF-C, tumor lymphangiogenesis and lymphatic metastasis (P< 0.05), however not gender, tumor size, tumor location, Lauren classification and serosa invasion (P< 0.05).
CONCLUSIONSIn gastric cancer, the expression of COX-2 is significantly associated with VEGF-C expression, lymphangiogenesis and lymphatic metastasis. COX-2 may up-regulate the expression of VEGF-C, which induces lymphangiogenesis and accordingly contributes to lymphatic metastasis.
