Expressions of RhoC, CD44v6 and ICAM-1 in human gastric cancer and its clinicopathological significance.
- Author:
Zeng-qiang ZHAO
1
;
Pei-wu YU
;
Yong-liang ZHAO
;
Yan SHI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Humans; Hyaluronan Receptors; metabolism; Immunohistochemistry; Intercellular Adhesion Molecule-1; metabolism; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Stomach Neoplasms; metabolism; pathology; rho GTP-Binding Proteins; metabolism; rhoC GTP-Binding Protein
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(4):352-355
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of RhoC, CD44v6 and ICAM-1 in gastric cancer and their correlations.
METHODSSABC immunohistochemistry was used to detect the expressions of RhoC, CD44v6 and ICAM-1 in the specimens from 40 cases with gastric cancer. Their correlations were reviewed by clinicopathological data.
RESULTSThe expression of RhoC, CD44v6 and ICAM-1 were not correlated with tumor differentiation and invasion depth (P> 0.05), but significantly correlated with lymph metastasis and pTNM stage (P< 0.05). There was a significant correlation between the expression of RhoC and the expression of CD44v6 or ICAM-1 (r=0.355, P=0.006; r=0.354, P=0.003) respectively. If RhoC was positive-expressed, and either of CD44v6 or ICAM-1 was positive-expressed, the sensitivity and the specificity for predicting the lymphatic metastasis was 93.75%, 62.5% respectively.
CONCLUSIONSThe positive expressions of RhoC, CD44v6 and ICAM-1 are useful biological markers for predicting the metastatic potential of gastric cancer. The combined detection of three markers is a useful method for predicting lymphatic metastasis of gastric cancer.
