Evaluation of the minimal invasiveness of laparoscopic operation for colorectal carcinoma.
- Author:
Xiang HU
1
;
Hai-zhi LI
;
Jian ZHANG
;
Wei-de AN
;
Cai-jia ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; C-Reactive Protein; metabolism; Colorectal Neoplasms; blood; pathology; surgery; Female; Humans; Intercellular Adhesion Molecule-1; blood; Interleukin-6; blood; Interleukin-8; blood; Laparoscopy; Male; Middle Aged; Postoperative Period; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(5):404-406
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the minimal invasiveness of laparoscopic operation for colorectal carcinoma.
METHODSForty cases with pathologically proven colorectal carcinoma were divided into laparoscopic group (n=20) and open surgical group (n=20). Perioperative alterations of peripheral blood IL-6, IL-8, TNF-alpha, CRP, sICAM-1 and WBC CD11b were compared between the two groups. TNF-alpha, IL- 6, IL- 8 and sICAM-1 were determined by ELISA, CRP by scattered radiation turbidity comparison and WBC CD11b by flow cytometry with monoclonal antibody PS- CD11b, M2Ab.
RESULTSThe postoperative cytokine levels of TNF-alpha, IL-6 and IL-8 in open surgery group were significantly higher than those in laparoscopic group (P< 0.05). Dynamic level of sICAM-1 at 6 and 24 hours after operation in open surgery group were significantly higher than those in laparoscopic group. Peripheral WBC CD11b decreased to the lowest level at 6 hours after operation in open surgery group,significantly lower than that in laparoscopic group (P< 0.05).
CONCLUSIONLaparoscopic surgery for colorectal carcinoma exerts less effects on patients than traditional open surgery, and can maintain patients defense function,therefore it is less invasive.
