Relationship of vascular endothelial growth factor-C and lymphangiogenesis with the development and prognosis of colon cancer.
- Author:
Jin-bo JIANG
1
;
Xue-mei LI
;
Wei-dong ZHANG
;
Min ZHU
;
Nan-hai SHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Colonic Neoplasms; metabolism; pathology; Female; Humans; Lymphangiogenesis; Lymphatic Metastasis; Lymphatic Vessels; Male; Middle Aged; Prognosis; Vascular Endothelial Growth Factor C; metabolism; Vascular Endothelial Growth Factor Receptor-3; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2005;8(6):516-519
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation of vascular endothelial growth factor-C (VEGF- C) expression and lymphatic microvessel density (LMVD) with clinicopathological features and prognosis in colon cancer.
METHODSThe expression of VEGF-C and VEGFR-3 was detected by immunohistochemical staining with monoclonal antibodies against VEGF-C and VEGFR-3 in 44 cases with primary colon cancer. LMVD was calculated.
RESULTSVEGF-C positive rate was 43.2% (19/44). VEGF-C expression was associated with tumor (P=0.003), lymph node metastasis (P=0.002), Dukes stage (P=0.001). The mean LMVD was 10.14+/- 4.19. LMVD was associated with lymph node metastasis (P=0.002), Dukes stage (P=0.001). LMVD in VEGF-C(+) group was (11.34+/- 4.83) higher than (9.24+/- 3.48) in VEGF-C(-) group, but there was no statistically significance between the two groups (P=0.105). The survival rate of the patients with positive VEGF-C was lower than that with negative VEGF-C (P=0.0225). The median survival time of the patients with LMVD(+) group was shorter than that with LMVD(-) (P=0.0036). Distant metastasis (P=0.0004), lymphatic metastasis (P=0.021) and LMVD (P=0.0469) were independent prognostic factors.
CONCLUSIONSVEGF-C and LMVD appear to be new prognostic factors for colon cancer. Furthermore, LMVD may be a new independent prognostic factor.
