Protective effect of glutamine on intestinal barrier function in patients receiving chemotherapy.
- Author:
Hai-ping JIANG
1
;
Chun-an LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; Female; Gastrointestinal Neoplasms; drug therapy; therapy; Glutamine; administration & dosage; therapeutic use; Humans; Intestinal Mucosa; drug effects; Male; Middle Aged; Postoperative Period
- From: Chinese Journal of Gastrointestinal Surgery 2006;9(1):59-61
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of glutamine (Gln) on intestinal permeability in patients receiving chemotherapy.
METHODSThirty-nine patients with gastrointestinal cancer after operation were randomly divided into Gln and control groups, and received oral administration of glutamine (30 g/d) for 7 days (n=22) or not (n=17). All patients received CF+ 5-FU chemotherapy for 5 days. Serum concentration of glutamine and urinary lactulose/mannitol (L/M) ratio were measured before and 1 day after chemotherapy.
RESULTSAfter chemotherapy, the serum Gln concentration was significantly decreased to (535.42+/- 53.75) micromol/L in the control group and increased to (54.44+/- 81.26) micromol/L in the Gln group, and there was significant difference between the two groups (P< 0.01). Urine L/M ratio was significantly increased to (0.0453+/- 0.0078) in the control group and decreased to (0.0331+/- 0.0061) in the Gln group, and there was significant difference between the two groups after chemotherapy (P< 0.01).
CONCLUSIONOral administration of glutamine granules can increase serum concentration of glutamine in chemotherapy patients with gastrointestinal cancer and can decrease intestinal permeability, maintain intestinal barrier.
